Abstract: Objective：To investigate the correlations of serum cystatin C levels, cystatin C gene +148 and +73 polymorphism and metabolic syndrome (MS) of Chinese Zhuang and Han population in Guangxi region. Methods：A hundred MS patients and healthy individuals for each group of Zhuang and Han population were selected in this study. Serum cystatin C levels were determined by immunoturbidimetric assay. Gene polymorphism of CysC+148 and +73 were detected by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP). The correlations between serum CysC level, CysC gene polymorphism and MS in Zhuang and Han population were analized. Results：There were significant differences of serum CysC levels between the two MS groups and healthy controls group (all P<0.05), but no significant difference of the genotype frequencies of CysC+73 and CysC+148 in the four groups was observed（χ²=3.139，P=0.791；χ²=4.841，P=0.564）. The serum Cys C levels of CysC+73 GG genotype in both MS groups were lower than those of CysC+73 AG and AA genotype with statistically significant differences (allP<0.05). The serum Cys C levels in MS groups were correlated with serum creatinine levels (P<0.01) and CysC+73 gene polymorphism (P<0.01). Conclusion：The serum Cys C level of the MS patients in Zhuang and Han population may vary with the genotype of CysC+73 genetic variant, and associate with serum creatinine level.