维持性血透治疗的2型糖尿病肾病患者血浆eotaxin-2、sTNFRⅡ等表达水平与代谢综合征状态的关系
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

镇江市2014年度社会发展科技支撑项目(SH2014051);江苏省检验医学重点实验室开放基金项目(JSKLM-2014-012);江苏省重点研发计划项目(BE2016716)。


Correlations of plasma eotaxin-2, sTNFR Ⅱ and other cytokines levels with the status of metabolic syndrome in type 2 diabetic nephropathy patients treated with maintenance hemodialysis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    摘要:目的: 探讨维持性血透(MHD)治疗的2型糖尿病肾病(DN)患者血浆嗜酸性粒细胞趋化因子-2(eotaxin-2)、可溶性肿瘤坏死因子受体Ⅰ、Ⅱ(sTNFRⅠ、Ⅱ)等表达水平与代谢综合征(MS)状态的关系。 方法:选取接受MHD治疗3个月以上且病情稳定的DN患者30例,以首次确诊且尚未实施任何治疗的单纯2型糖尿病(T2D)患者和体检健康者各30例为对照;检测MS相关指标血压、腰围、体质指数、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)等;AAH-INF-G3抗体芯片法分析40种细胞因子的表达水平;Pearson法分析其与MS相关指标的相关性。 结果:DN患者和T2D患者MS发生率分别为88.89%和33.33%。与T2D患者和健康人对照者相比,DN患者有较多的MS危险因素个数、较高的腰围和较低的体质指数;血浆eotaxin-2和趋化因子I-309水平升高,同时伴有sTNFRⅠ、Ⅱ的表达水平升高。Pearson相关分析提示,血浆eotaxin-2、I309与MS危险因素TG、FBG及舒张压(DBP)水平等呈现明显正相关。此外,血浆sTNFRⅡ和I-309表达水平均与CRP水平呈显著正相关。 结论:MHD治疗的DN患者机体内存在着消耗性MS微炎症状态。糖脂代谢的异常影响机体的免疫生理状态,造成免疫炎症微环境。eotaxin2、I-309可能参与这种微炎症状态的慢性化、持续化,并进一步通过sTNFRⅠ、Ⅱ的上调而加重肾脏损伤,导致MHD治疗的DN患者MS状态的形成。

    Abstract:

    Abstract: Objective:To investigate the correlations of plasma eotaxin-2, soluble tumor necrosis factor receptor(sTNFR) Ⅱ and other cytokines levels with the status of metabolic syndrome(MS) in type 2 diabetic nephropathy(DN) patients treated with maintenance hemodialysis(MHD). Methods:Thirty type 2 DN patients with stable pathogenetic conditions and MHD treatment for more than 3 months, thirty newly diagnosed and untreated type 2 diabetes(T2D) patients and thirty healthy volunteers were enrolled in the study. The MS related markers, including blood pressure, waist circumference, body mass index, triglyceride(TG), high density lipoprotein cholesterol(HDL-C), fasting blood glucose(FBG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and C reactive protein(CRP), were determined. The expression levels of 40 cytokines were detected with the AAH-INF-G3 antibody microarray, and their correlations with MS related markers were analyzed by the Pearson method. Results:The incidence rates of MS in DN patients with MHD and T2D patients were 88.89% and 33.33%, respectively. Compared with T2D patients and healthy controls, the DN patients had more MS related markers, higher waist circumference and lower body mass index, and their plasma eotaxin-2, I-309 and sTNFRⅠ/Ⅱ levels increased significantly. Pearson correlation analysis showed that plasma eotaxin-2 and I-309 levels were positively related to MS risk factors such as TG, FBG and diastolic blood pressure(DBP) levels. Plasma sTNFR Ⅱ and I-309 levels were significantly positively correlated with plasma CRP levels. Conclusion:A micro inflammatory state exists in type 2 DN patients with MHD. Abnormal glycolipid metabolism may influence on the immunologic and physiological state of human body, and then form the micro inflammatory state. Eotaxin-2 and I-309 may participate in this chronic and persistent process and further induce renal damage by upregulating sTNFR Ⅰ/Ⅱ levels, which may result in the formation of MS state in type 2 DN patients with MHD.

    参考文献
    相似文献
    引证文献
引用本文

路萍,许化溪,苏兆亮.维持性血透治疗的2型糖尿病肾病患者血浆eotaxin-2、sTNFRⅡ等表达水平与代谢综合征状态的关系[J].临床检验杂志,2017,(7):507-510

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2017-03-13
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2017-08-15
  • 出版日期:
您是第位访问者  苏ICP备12051282号-1
主管单位:江苏省医学会  出版单位:临床检验杂志
单位地址:江苏省南京市中央路42号  邮编:210008
电话:025-83620683 E-MAIL:lcjyzz@163.com
技术支持:北京勤云科技发展有限公司