Abstract:Abstract: Objective:To investigate the correlations of plasma eotaxin-2, soluble tumor necrosis factor receptor(sTNFR) Ⅱ and other cytokines levels with the status of metabolic syndrome(MS) in type 2 diabetic nephropathy(DN) patients treated with maintenance hemodialysis(MHD). Methods:Thirty type 2 DN patients with stable pathogenetic conditions and MHD treatment for more than 3 months, thirty newly diagnosed and untreated type 2 diabetes(T2D) patients and thirty healthy volunteers were enrolled in the study. The MS related markers, including blood pressure, waist circumference, body mass index, triglyceride(TG), high density lipoprotein cholesterol(HDL-C), fasting blood glucose(FBG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and C reactive protein(CRP), were determined. The expression levels of 40 cytokines were detected with the AAH-INF-G3 antibody microarray, and their correlations with MS related markers were analyzed by the Pearson method. Results:The incidence rates of MS in DN patients with MHD and T2D patients were 88.89% and 33.33%, respectively. Compared with T2D patients and healthy controls, the DN patients had more MS related markers, higher waist circumference and lower body mass index, and their plasma eotaxin-2, I-309 and sTNFRⅠ/Ⅱ levels increased significantly. Pearson correlation analysis showed that plasma eotaxin-2 and I-309 levels were positively related to MS risk factors such as TG, FBG and diastolic blood pressure(DBP) levels. Plasma sTNFR Ⅱ and I-309 levels were significantly positively correlated with plasma CRP levels. Conclusion:A micro inflammatory state exists in type 2 DN patients with MHD. Abnormal glycolipid metabolism may influence on the immunologic and physiological state of human body, and then form the micro inflammatory state. Eotaxin-2 and I-309 may participate in this chronic and persistent process and further induce renal damage by upregulating sTNFR Ⅰ/Ⅱ levels, which may result in the formation of MS state in type 2 DN patients with MHD.