儿童血管性血友病因子抗原和活性水平参考区间建立
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Establishment of reference intervals of von Willebrand factor antigen and activity for children
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    摘要:目的观察性别、 年龄和ABO血型对儿童血管性血友病因子( vWF)检测的影响并建立参考区间。方法随 机选取2022年1月至9月苏州大学附属儿童医院无出凝血临床表现且常规凝血检查结果均正常的857例儿童,检测其血浆vWF抗原和活性水平与ABO血型。结果≤6 岁儿童vWF抗原和活性水平低于>6岁且≤18岁儿童(P<0.05);在不同年龄分组中0型血儿童vWF水平均低于非0型血儿童(P<0.001)。 对于≤6岁儿童,0型血儿童vWF抗原和活性参考区间分别为44.4% ~ 130.6%和43.0%~ 194.7%;非0型血儿童vWF抗原和活性参考区间分别66.3%~ 190.4%和71.3%~ 282.3%。对于>6 .岁儿童,0型血儿童vWF抗原和活性参考区间分别为50.4%~ 145.4%和51.7%-221.4%;非0型血儿童vWF抗原和活性参考区间分别为75.4% ~ 195.6%和84.0%~296.5%。结论儿童 血浆vWF抗原和活性水平受年龄和ABO血型影响,实验室积极建立针对儿童vWF的特异性参考区间有利于临床全面评估患儿的出血与血栓风险。

    Abstract:

    Abstract : Objective To investigate the effects of gender, age, and ABO blood type on the detection of von W ilebrand factor ( vWF)antigen (vWF: Ag) and activity (vWF: Ac) in children, and establish the reference intervals of vWF: Ag and vWF: Ac for children.Methods 857 children who had no clinical manifestation of bleeding or coagulation and had normal results of routine coagulation tests were selected randomly from our hospital, and their plasma vWF: Ag and vWF: Ac and ABO blood type were detected. Results The levels of vWF: Ag and vWF: Ac in the low age group (≤6 years old ) were significantly lower than that in the high age group (>6 and≤18 years old, P<0.05). The levels of vWF: Ag and vWF: Ac in children with type 0 blood were significantly lower than that with non-O blood type in different age groups ( P<0.001). For children aged≤6 years , the reference intervals of vWF: Ag and vWF: Ac in the type 0 blood group were 44.4%-130.6% and 43.0% -194.7% , respectively, and those in the non-O blood type group were 66.3%-190.4% and 71.3%-282.3%, respectively. For children aged >6 and≤18 years, the reference intervals of vWF: Ag and vWF: Ac in the type 0 blood group were 50.4%-145.4% and 51.7%-221 .4% , respectively, and those in the non-O blood type were 75. 4%-195.6% and 84.0% -296.5%, respectively. Conclusion The levels of plasma vWF: Ag and vWF: Ac in children are afected by age and ABO blood type. Laboratories should actively establish the specifie reference intervals of vWF in children,which will be helpful for compre-hensively assessing the risk of bleeding and thrombosis in children.

    参考文献
    相似文献
    引证文献
引用本文

魏佳,申汉俊,薛建,谭秋霞.儿童血管性血友病因子抗原和活性水平参考区间建立[J].临床检验杂志,2023,41(01):32-34

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2022-08-29
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2023-05-22
  • 出版日期:
您是第位访问者  苏ICP备12051282号-1
主管单位:江苏省医学会  出版单位:临床检验杂志
单位地址:江苏省南京市中央路42号  邮编:210008
电话:025-83620683 E-MAIL:lcjyzz@163.com
技术支持:北京勤云科技发展有限公司