Abstract: Objective To explore the predictive values of blood coagulation index within 24 hours before delivery , pregnancy complications and maternal complications in postpatum hemorhage. Methods A total of 17 024 delivery of hospitalization in the Third Hospital of Peking Medical University from 2013 to 2018 were retrospectively analyzed by dividing into postpartum hemorrhage group (n=2 211) and the non-postpartum hemorhage group (n= 14 813) according to occurrence of postpartum hemorhage. The characteristics, clinical data and blood coagulation indexes within 24 hours before delivery of the two groups were compared. The risk factors of postpartum hemorrhage were analyzed by univariate and multiv ariate Logistic regression analysis. The receiver operating characteristic ( ROC) curve was used to assess the early predictive value for postpartum hemohage. Results Univariate Logistic regression analysis showed that the diferences for a variety of factors showed statistical differences between both groups , including age, gestational age at admission, multiple gestations, coagulation indicator， ie, fbrinogen ( Fib)，activated partial thromboplastin time ( APTT)，thrombin time (TT)，international normalized ratio ( INR)，preeclampsia, placental abruption, placental previa and placenta accreta(all P<0.05 ). Multivariate Logistic regression analysis showed that the increase of age, gestational age at admission and INR, multiple gestations，preecl ampsia, placental abruption, placental previa and placenta accrete were independent risk factors of post partum hemorrhage. ROC curve analysis showed that the AUCROC for the eardy prediction of postpartum hemorrhage by combined multiple index was 0.685 ( 95%CI: 0.672 to 0.698) and the accuracy was 87.7%. Conclusion Comprehensive analysis for the factors including maternal age, gestational age at admission, multiple gestations, blood coagulation index within 24 hours before delivery (Fib, APTT and INR), placenta-mediated pregnancy complications could be helpful for early prediction of postpartum hemorrhage.